Role of alkaline phosphatase Regan isoenzyme in prognosis of patients with osteosarcoma
Tucci, A.; Saviano, C.; Del Prete, S.
Medicina 10(2): 158-160
1990
ISSN/ISBN: 0392-6516 PMID: 2273951 Document Number: 363603
The presence of Regan isoenzyme (the heat stable fraction of alkaline phosphatase) in serum of patients with osteosarcoma has been proposed as a prognostic factor indicating the metastatic evolution of the disease. This work reports on 9 patients with osteosarcoma. In 4 of them Regan isoenzyme was present 4, 6, 12, and 16 months before clinical-instrumental evidence of lung metastases. These results further support the significance of this isoenzyme as a marker of relapse in an early subclinical stage.