Isolation and characterization of cell clones persistently producing teardrop-shaped particles of human immunodeficiency virus type 1
Morita, C.; Ikuta, K.; Goto, T.; Sano, K.; Nakai, M.; Hirai, K.; Kato, S.
Journal of Acquired Immune Deficiency Syndromes 3(3): 231-237
1990
ISSN/ISBN: 0894-9255 PMID: 2106023 Document Number: 363187
Several cell clones producing teardrop-shaped human immunodeficiency virus type 1 (HIV-1) particles were isolated from MT-4 cells that survived HIV-1 infection after extensive cell lysis. Most of the teardrop-shaped particles contained an electron-dense core structure, and the particles could replicate in MT-4 cells. No significant structural difference in the HIV-1 proteins was observed between these cell clones and the MOLT-4 cells producing intact HIV-1 particles, although their envelope structure is morphologically abnormal.
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