HLA-DR, DQ and DP antigen expression in synovial fluid T lymphocytes in rheumatoid arthritis: cell cycle analysis of HLA-DP positive T cells
Hirose, T.; Goto, M.; Okumura, K.
Journal of Rheumatology 17(1): 18-23
1990
ISSN/ISBN: 0315-162X PMID: 1690301 Document Number: 362764
Cell surface expression of HLA-DR, DQ and DP antigens on synovial fluid (SF) T cells was analyzed in 43 patients with rheumatoid arthritis. Marked increase in the positive expression of all 3 Ia antigens was observed in the SF T cells compared to the counterpart, peripheral blood T cells. Both the DNA and RNA content of HLA-DP+ T cells were analyzed using acridine orange stain. RNA content in the HLA-DP+ SF T cells increased in comparison to that in the HLA-DP- SF T cells or normal peripheral blood T cells. Our findings suggest that majority of the SF T cells are activated and express HLA-DP antigen, while not proliferating.