The serotoninergic mechanism and the experimental therapy of sleep disorders in desynchronization
Gromov, L.A.; Pishel', V.I.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 2: 22-23
1990
ISSN/ISBN: 0031-2991 PMID: 2381743 Document Number: 362623
The authors studied the dynamics of changes in the serotonin content in the brain of albino rats in development of experimental neurosis along the type of desynchronization and under the effect of essential amino acid L-tryptophan. It was found that disturbance in the sleep-awake cycle in desynchronization is attended with decrease in the serotonin level in the hemispheres and brain stem and leveling out the interhemispheric asymmetry. Injection of 80 mg/kg L-tryptophan in this condition leads to increase of the brain serotonin content and restoration of the normal physiological structure of the sleep-awake cycle.