N-depyridination and N-dedimethylaminoethylation of tripelennamine and pyrilamine in the rat. new metabolic pathways
Yeh, S.Y.
Drug Metabolism and Disposition the Biological Fate of Chemicals 18(4): 453-461
1990
ISSN/ISBN: 0090-9556 PMID: 1976067 Document Number: 362444
N-(2-Dimethylaminoethyl)benzylamine and 2-benzylaminopyridine were identified as two new urinary metabolites of tripelennamine in the rat by GC/MS. 2-(4-Methoxybenzylamino)-pyridine and N-(dimethylaminoethyl)-4-hydroxybenzylamine were identified as new urinary metabolites of pyrilamine by GC/MS. Thus, in addition to N- and O-demethylation, hydroxylation, and glucuronidation, N-debenzylation, N-depyridination and N-dedimethylaminoethylation were shown to be novel pathways for metabolism of tripelennamine and pyrilamine. The mechanism for N-depyridination and N-dealkylation is discussed.