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Long-term maintenance therapy in duodenal ulcer. Efficacy and safety

Penston, J.; Wormsley, K.G.

Fortschritte der Medizin 108(14): 282-286

1990

ISSN/ISBN: 0015-8178
PMID: 2373457
Document Number: 362360
The efficacy and safety of continuous (maintenance) treatment with ranitidine has been studied retrospectively in 388 patients with duodenal ulcer. The cumulative rate of symptomatic relapse was 16% after 5 years. Very few of the patients developed ulcer complications during maintenance treatment, with a cumulative risk of haemorrhage of 1.8% during 5 years. The patients developed no drug-related disease. We conclude that long-term, continuous treatment with ranitidine is effective in maintaining remission of duodenal ulcers, protects the patients against the risk of complications, and is safe.

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