Efficacy of GH-releasing hormone and biosynthetic GH in a group of children with growth hormone deficiency
Biscaldi, I.; Fiori, A.; Moretta, A.; Valtorta, A.
Medicina 10(2): 145-146
1990
ISSN/ISBN: 0392-6516 PMID: 2273946 Document Number: 362311
Eight GH-deficient children were treated with GHRH (1-44), once daily s.c. for 6-18 months. At the 6th month of therapy, 3 patients showed a catch-up growth ("responders"), while the remaining 5 did not ("non-responders"). In all patients treatment was discontinued after 6-18 months, when its effect on growth rate failed. After a wash out period of at least 6 months, patients were submitted to biosynthetic GH therapy. After 6 months of GH treatment a significant catch-up growth was found in both responder and non-responder children. GHRH therapy is found to be less effective than GH treatment. Other methods of GHRH administration are worth investigating.