Cerebrospinal fluid study in Chinese patients with multiple sclerosis
Tsai, S.J.; Chiu, H.C.; Su, C.L.; Wang, C.R.
Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 23(2): 189-196
1990
ISSN/ISBN: 0253-2662 PMID: 2394192 Document Number: 361809
The demonstration of intrathecally synthesized IgG had been known to be one of the most important aids in diagnosis of multiple sclerosis (MS). Three quantitative methods (CSF IgG, IgG index, de novo IgG synthesis rate) and qualitative detection of oligoclonal band (OB) were used in this study. We collected CSF and serum samples from 22 patients, including 14 with clinically definite MS (DMS) and 8 with clinically possible MS (PMS). The 3 quantitive CSF IgG indeces were significantly increased in DMS group (p<0.05) as compared with normal control group, but not in PMS group. There was no difference in the positive rate of OB between DMS and PMS (both are 50%). The relationship between IgG indeces and various clinical condition in DMS patients are as following: The 3 CSF IgG indeces were increased only in the patients with younger age onset, shorter duration, higher relapsing rate, spinal form and disease in relapsing stage. The positive rate of OB was increased only in the patients with longer duration and higher relapsing rate. The follow-up study showed the presence of OB was not change while the disease was remissive. It was concluded that CSF IgG, IgG index, de novo IgG synthesis rate had good correlation with clinical diagnosis, and were good reference for clinical course, disease activity, and therapeutic effect in Chinese patients with MS. The diagnostic value of OB in this study was not so prominent as the reports by other authors.