Dissolution of bile duct stones with monooctanoin: in vitro study
Pozzi, C.; Tritapepe, R.; Di Padova, C.; Montorsi, M.; Cesana, B.
International Surgery 75(4): 240-243
1990
ISSN/ISBN: 0020-8868 PMID: 2292483 Document Number: 361634
Mono-octanoin (Mo) is the drug of choice in the topical litholytic treatment of residual gallstones following cholecystectomy. Although this drug does not produce significant side effects, it requires a lengthy period of treatment (15-20 days). The purpose of this study was to verify the in vitro efficacy of the mixture Mo + 10% H2O vs pure Mo in human cholesterol stones. The findings indicate that this mixture can reduce dissolution time by 15.8% and increase the dissolution rate by 27.9% vs pure Mo. A further significant reduction (p = 0.0001) in dissolution times can be obtained by constant exchange of the solvent at the surface of the stone (stirring).