Top Abstract Purchase Related
Home
>
Node
>
Subnode

Prospects for gene therapy of familial hypercholesterolemia

Wilson, J.M.; Chowdhury, J.R.

Molecular Biology and Medicine 7(3): 223-232

1990

ISSN/ISBN: 0735-1313
PMID: 2215208
Document Number: 361590
Familial hypercholesterolemia is an inherited disease in humans that is caused by a deficiency in the receptor that mediates the internalization and degradation of low density lipoprotein. Patients that inherit two abnormal low density lipoprotein receptor alleles have severe hypercholesterolemia, advanced atherosclerosis, and life-threatening coronary artery disease that is refractory to conventional therapies. In this review, we discuss the prospects for gene therapy in the treatment of familial hypercholesterolemia.

Document emailed within 1 workday
Secure & encrypted payments

Freiberger, T.; Kuhrová, V.; Kozák, L.; Soska, V.; Pekarík, V.; Mĕrínská, L.; Fajkusová, L.; Francová, H. 1998: Direct detection of mutations in the LDL receptor gene in patients with familial hypercholesterolemia Casopis Lekaru Ceskych 137(24): 750-752
Mandel'shtam, M.I.; Lipovetskiĭ, B.M.; Shvartsman, A.L.; Gaĭtskhoki, V.S. 1995: A multiexon deletion in the human low density lipoprotein receptor gene as a reason for familial hypercholesterolemia Genetika 31(2): 259-263
Ferrières, J.; Lambert, J.; Lussier-Cacan, S.; Davignon, J. 1995: Coronary artery disease in heterozygous familial hypercholesterolemia patients with the same LDL receptor gene mutation Circulation 92(3): 290-295
Meshkov, A.N.; Stambol'skiĭ, D.V.; Krapivner, S.R.; Bochkov, V.N.; Kukharchuk, V.V.; Malyshev, P.P. 2004: Low density lipoprotein receptor gene mutations in patients with clinical diagnosis of familial hypercholesterolemia Kardiologiia 44(9): 58-61
Williams, R.R.; Hasstedt, S.J.; Wilson, D.E.; Ash, K.O.; Yanowitz, F.F.; Reiber, G.E.; Kuida, H. 1986: Evidence that men with familial hypercholesterolemia can avoid early coronary death. An analysis of 77 gene carriers in four Utah pedigrees JAMA 255(2): 219-224
Shiomi, M.; Ito, T.; Watanabe, Y. 1987: Hypercholesterolemia and atherosclerosis in the WHHL rabbit, an animal model of familial hypercholesterolemia Progress in Clinical and Biological Research 229: 35-40
Kuŝić, M.; Gavrilović, M.; Mihajloviĉ, M.; Boŝković, B. 1980: Results of 6 months, therapy of familial hypercholesterolemia (hyperlipoproteinemia type II) with colestipol Srpski Arhiv Za Celokupno Lekarstvo 108(9): 875-881
Krapivner, S.R.; Malyshev, P.P.; Rozhkova, T.A.; Potaraus, A.B.; Kukharchuk, V.V.; Bochkov, V.N. 2000: Application of DNA analysis for differential diagnosis of familial hypercholesterolemia and familial defect of apolipoprotein b-100 Terapevticheskii Arkhiv 72(4): 9-12
Cohen-Haguenauer, O.; Boiron, M. 1992: Gene therapy: facts and prospects Pathologie-Biologie 40(1): 5-13
Jansen, S.; Zambrana, J.L.; López Miranda, J.; Blanco, A.; Blanco, J.; Jiménez Perepérez, J.A.; Espino, A.; Pérez Jiménez, F. 1995: Possible relationship between overweightness and prevalence of hyperlipemia in the children of patients with heterozygote familial hypercholesterolemia and combined familial hyperlipemia Medicina Clinica 105(3): 85-88
Byrnes, A.P. 2005: Challenges and future prospects in gene therapy Idrugs: the Investigational Drugs Journal 8(12): 993-996
Malech, H.L.; Bauer, T.R.; Hickstein, D.D. 1997: Prospects for gene therapy of neutrophil defects Seminars in Hematology 34(4): 355-361
Yoshida, O.; Kamidono, S. 1997: Molecular urology: the present situation and prospects of gene therapy Hinyokika Kiyo. Acta Urologica Japonica 43(11): 805-807
Akazawa, H.; Komuro, I. 2007: Current view and prospects of gene therapy for heart failure Nihon Rinsho. Japanese Journal of Clinical Medicine 65 Suppl. 4: 35-40
Nakahara, N.; Yoshida, J. 2005: Gene therapy for brain tumors--present conditions and prospects Gan to Kagaku Ryoho. Cancer and ChemoTherapy 32(4): 458-462
Hargest, R.; Eldin, A.; Williamson, R. 1998: Gene therapy for familial adenomatous polyposis. Prolonged expression of the adenomatous polyposis coli gene after lipofection into mouse colon in vivo Advances in Experimental Medicine and Biology 451: 385-391
Lahoz, C.; Mostaza, J.M. 1999: Familial hypercholesterolemia. Are we different in this also? Medicina Clinica 113(14): 533-534
Widhalm, K. 2000: Familial hypercholesterolemia Deutsche Medizinische Wochenschrift 125(4): 99
Sozzi, G.; Andriani, F.; Gramegna, M.; Roz, L. 2002: Involvement of FHIT in lung carcinogenesis prospects for future clinical gene therapy applications I Suppli di Tumori: Official Journal of Societa Italiana di Cancerologia . 1(4): S62
Romano, G.; Claudio, P.P.; Kaiser, H.E.; Giordano, A. 1998: Recent advances, prospects and problems in designing new strategies for oligonucleotide and gene delivery in therapy In Vivo 12(1): 59-67