Beta 2-microglobulin in the diagnosis of specific involvement of the kidneys in acute leukemias
Vorob'ev, V.G.; Trunova, E.M.; Borovkov, N.N.
Laboratornoe Delo 1990(10): 31-34
1990
ISSN/ISBN: 0023-6748 PMID: 1704452 Document Number: 359666
Measurements of the serum and urinary .beta.2-microglobulin (.beta.2-Mg) concentrations in 138 adult patients with various forms of acute leukemia, which were carried out in various periods of the disease, have revealed that serum .beta.2-Mg levels were two times higher in the patients with leukemic involvement of the kidneys (5.54 .+-. 3.50 mg/l) than in those without renal involvement (2.77 .+-. 1.07 mg/l). Consequently, urinary .beta.2-Mg excretion was much higher in the patients with renal involvement than in those with intact kidneys (1.512 .+-. 3.222 mg/l vs. 0.388 .+-. 1.175 mg/l). Mathematical analysis has shown that the risk of leukemic involvement of the kidneys makes up 93.3 percent in acute leukemia patients with serum .beta.2-Mg levels surpassing 6.0 mg/l. This permitted a conclusion on the diagnostic value of .beta.2-Mg measurements for the detection of specific involvement of the kidneys in acute leukemia.