A karyotype and chromatin study of the peripheral blood lymphocytes of patients with pigmented skin neoplasms
Ganina, K.P.; Naleskina, L.A.; Kireeva, S.S.
Tsitologiia i Genetika 24(2): 16-21
1990
ISSN/ISBN: 0564-3783 PMID: 2375052 Document Number: 359482
Rearrangements of genetic material in the peripheral blood lymphocyte nuclei have been found in patients with dysplastic pigmented nevi and malignant melanomas (15 cases), in contrast to the control (10 healthy persons). It is expressed as an increase in the number of chromosome aberrations in the karyotype and as a change of the Feulgen-positive substance correlation in the interphase nuclei of the given cells towards an increase in the active-functioning DNA structures.