Prenatal diagnosis of chromosomal disorders in Delhi
Verma, I.C.; Mathew, S.; Elango, R.; Khanna, I.
Indian Pediatrics 27(5): 459-462
1990
ISSN/ISBN: 0019-6061 PMID: 2276773 Document Number: 359439
Prenatal diagnosis of chromosomal disorders was carried out in 144 samples of amniotic fluid during 1986-1989. The commonest indication was pregnancy in women having a previous child with Down syndrome. Cultures were successful in 104 (72.2%) of 144 cases. Three (2.9%) abnormal karyotypes were detected. Of 53 women who had a previous child with Down syndrome, recurrence of trisomy 21 occur d in one (1.9%); while considering all abnormal karyotypes, there were three recurrences (2.9%).