Effect of leu- (Asp, Asn, Glu, Gln) dipeptides on platelet aggregation in vitro
Liakopoulou-Kyriakides, M.; Stavropoulos, G.; Karagiannis, C.; Calogridis, P.; Sinakos, Z.
Biochemistry International 22(4): 617-625
1990
ISSN/ISBN: 0158-5231 PMID: 2078190 Document Number: 358317
A series of Leu-(Asp, Asn, Glu, Gln) dipeptides were synthesized and tested for their effect on human platelet aggregation in vitro induced by collagen, ADP, or adrenaline. It was found that only Leu-Asp-NH2 and Leu-Asn-NH2 inhibit rather strongly platelet aggregation, whereas a small inhibition was observed with Leu-Glu-NH2 and Leu-Gln-NH2, respectively.
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