Indomethacin attenuates early postischemic vasogenic edema and cerebral injury
Ting, P.
Advances in Neurology 52: 119-126
1990
ISSN/ISBN: 0091-3952 PMID: 2396508 Document Number: 358188
Inhibition of cyclooxygenase products by IND given during and after temporary MCAO produced a marked reduction in the incidence of early postischemic BBB opening to albumin, despite the presence of reactive hyperemia. This beneficial effect might be due to direct prevention of endothelial cell damage by inhibition of prostaglandin synthesis. Reduction was insignificant in postischemic brain edema: however, the intensity of postischemic neuronal damage was reduced by IND.