Clinical studies on endocrine therapy of prostatic carcinoma (3) : Histopathological features of prostatic carcinoma and its prognosis
Kumamoto, Y.; Tsukamoto, T.; Umehara, T.; Harada, M.; Shimazaki, J.; Fuse, H.; Oshima, H.; Takeuchi, H.; Yoshida, O.; Okada, K.
Hinyokika Kiyo. Acta Urologica Japonica 36(3): 295-305
1990
ISSN/ISBN: 0018-1994 PMID: 2191571 Document Number: 357865
We investigated how histopathological features, such as structural atypism (SAT), nuclear anaplasia (NAN) and Gleason's pattern, influence the prognosis of patients receiving endocrine therapy. Patients with SAT 3 or NAN 3 clearly had a lower survival rate and a shorter survival period than those with other grades of SAT or NAN and this tendency was more prominent in the high stage than low stage. Patients with a higher grade of SAT or NAN had a poorer prognosis as well, when only cancer-related death was considered in the calculation of survival and survival period. The results described above suggest that the grade of SAT and NAN is one of most influential factors for prognosis. In the analysis for the prognosis of patients according to grade of