The effect of perivascular denervation on endothelium-dependent relaxation to acetylcholine
Miller, M.E.; Scott, T.M.
Artery 17(5): 233-247
1990
ISSN/ISBN: 0098-6127 PMID: 2118755 Document Number: 357552
We have examined the effect of perivascular denervation on the ability of acetylcholine to produce endothelium-dependent relaxation in the isolated perfused mesenteric arterial bed. Treatment with capsaicin prevented the development of substance P and calcitonin gene-related peptide containing perivascular nerve fibres. Treatment with 6-hydroxydopamine prevented the development of catecholaminergic perivascular nerve fibres. In the arterial beds from capsaicin treated rats there was a depression of the ability of Acetylcholine to produce endothelium dependent relaxation. No change in endothelium-dependent relaxation to ACh was found in 6-hydroxydopamine treated rats.