Human immunodeficiency virus cultured from bone. Implications for transplantation
Buck, B.E.; Resnick, L.; Shah, S.M.; Malinin, T.I.
Clinical Orthopaedics and Related Research 251: 249-253
1990
ISSN/ISBN: 0009-921X PMID: 2295182 Document Number: 357532
This study demonstrates by a virologic culture method that human immunodeficiency virus (HIV) resides in bone. After freezing, some initially positive specimens no longer yielded virus, but those that continued to yield virus were not further altered by subsequent washing, which removed essentially all marrow, or by freeze-drying. The safeguards against potential transmission of HIV by a bone allograft are principally the screening and testing methods previously described, although there may be a further reduction of the remote residual risk by the freezing step in the usual technical sequence for tissue banking by sterile techniques.
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