Effects of verapamil on behavioral and microcirculatory disorders in pain syndrome of spinal etiology
Kryzhanovskiĭ, G.I.; Gorizontova, M.P.; Igon'kina, S.I.; Speranskaia, T.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 109(5): 425-428
1990
ISSN/ISBN: 0365-9615 PMID: 2378946 Document Number: 357360
In the experiments on Wistar rats with pain syndrome of spinal origin (PSSO) caused by the generator of pathologically enhanced excitation (GPEE) in dorsal horns of the spinal cord lumbosacral segments, it was shown that the intravenous verapamil injection (1.25 mg/kg) undoubtedly decreased behaviour response and improves the state of microcirculation. The compound of 10-fold decreased dose does not affect the behaviour response and microcirculation. When PSSO exists, the intravenous injection of analgin (150 mg/kg) produced an effect on the behaviour response and does not produce any action on microcirculation. When verapamil reaches the dorsal surface of the spinal cord (GPEE area) it decreases the behaviour response and microcirculation disorders created in PSSO. The obtained data make it clear that the GPEE depression caused by the verapamil calcium channel blocker weakens PSSO and normalizes the microcirculation.