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Rheoencephalographic and electroencephalographic studies on nicergoline

Dikova, M.; Tsikalova, R.; Nikolov, R.; Nikolova, M.; Patroneva, A.

Methods and Findings in Experimental and Clinical Pharmacology 12(5): 309-313

1990

ISSN/ISBN: 0379-0355
PMID: 2232965
Document Number: 357223
The effect of nicergoline on the rheoencephalogram (REG) and on spontaneous electroencephalographic activity (EEG) was studied in acute experiments in cats. The following REG parameters were assayed: amplitude, anacrotic section of the curve and its relative part and dicrotic index. EGG spectra were derived from 10-sec samples of ECoG and the relative amplitude was estimated at 2-Hz-intervals from 0-44 Hz. The REG study showed that nicergoline (0.05 mg/kg i.v.) cuased an increase of the amplitude, and a decrease of the anacrote, of the relative part of the anacrote and the dicrotic index - changes indicating a lowering of cerebrovascular resistance. EEG study showed a decrease of the slow activities (theta and delta), and an increase of the fast activities (alpha and beta-1).

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