Multiple organ failure: inflammatory priming and activation sequences promote autologous tissue injury
Anderson, B.O.; Harken, A.H.
Journal of Trauma 30(12 Suppl): S44-S49
1990
ISSN/ISBN: 0022-5282 PMID: 2174983 Document Number: 355995
Systemic inflammation promotes multiple organ failure through the induction of diffuse microvascular leak. Inflammatory cells such as neutrophils propagate this process. Tissue injury by neutrophils may be viewed as a normal process, inflammation, that has become uncontrolled and generalized. Multiple inflammatory stimuli synergistically promote neutrophil-mediated tissue injury in priming and activation sequences. In some settings, cellular priming is mediated by platelet-activating factor and can be prevented by platelet-activating factor antagonists. Inhibiting cellular priming could be efficacious in the therapy of multiple organ failure.