Control of spinal motor system by descending noradrenergic neuron
Fukuda, H.; Ono, H.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 96(1): 1-9
1990
ISSN/ISBN: 0015-5691 PMID: 1976578 Document Number: 355677
The physiological function of the descending noradrenergic system in the spinal ventral horn has not yet been fully elucidated. Here we describe our recent findings showing the motor function of the noradrenergic fibers. (1) .alpha.1-antagonists and .alpha.2-agonists depressed the spinal mono- and polysynaptic reflex potentials in rats that have an intact connection between the spinal cord and the brain. In rats spinalized at the C1 level, the .alpha.1-agonistic action of adrenergic agents increased the spinal reflexes. (2) In the radio frequency-lesioned decerebrate rigidity model of rats, .alpha.1-antagonists and .alpha.2-agonists reduced the rigidity by affecting the spinal and supraspinal levels, respectively. (3) .alpha.2-Agonists but not .alpha.1-antagonists reduced noradrenaline released into the subarachnoid space of anesthetized rats. (4) In a slice preparation isolated from adult rats, the .alpha.1-agonistic action of adrenergic agents increased the excitatory synaptic transmission of the ventral horn. Thus, it was demonstrated that .alpha.2-agonistic action at the brain stem inhibited spinal motor activity by reducing the release of noradrenaline in the spinal cord, and that the facilitatory action through .alpha.1-adrenoceptors was dominant in descending noradrenergic transmission in the motor nuclei of the ventral horn.