Baroreceptor resetting facilitates the onset of one-kidney, one clip hypertension
Salgado, H.C.; Machado, B.H.
Brazilian Journal of Medical and Biological Research 23(11): 1165-1170
1990
ISSN/ISBN: 0100-879X PMID: 2133026 Document Number: 355557
1. A previous study from our laboratory demonstrated the occurrence of transient tachycardia during the onset of one-kidney, one clip (1K1C) hypertension in conscious rats. In the present study, using electroneurographic recordings in anesthetized rats, we investigated the time course of baroreceptor resetting at the onset (3, 7, 14 and 21 days) of 1K1C hypertension. 2. There was no significant difference between the diastolic pressure of hypertensive animals and the systolic threshold pressure for baroreceptor activation in normotensive control rats (100 +/- 3 vs 92 +/- 5 mmHg), and hypertensive rats 3 (118 +/- 3 vs 112 +/- 5 mmHg), 7 (125 +/- 6 vs 119 +/- 5 mmHg), 14 (135 +/- 11 vs 125 +/- 10 mmHg) and 21 (154 +/- 6 vs 150 +/- 8 mmHg) days after clipping. 3. These data indicate that the baroreceptors were completely reset to the hypertensive levels during the periods studied and also suggest that baroreceptor resetting may play a facilitatory role for the onset of tachycardia and the development of 1K1C hypertension in the conscious animal model.