Arterial hypertension of unclear etiology as a complication of anesthesia during heart surgery under conditions of artificial circulation
Darbinian, T.M.; Zatevakhina, M.V.; Grigoliia, G.N.; Kuliev, E.A.
Vestnik Akademii Meditsinskikh Nauk SSSR 3: 11-17
1990
ISSN/ISBN: 0002-3027 PMID: 2353529 Document Number: 355531
The paper deals with causes of arterial hypertension in the early postperfusion and postoperative periods in treating congenital heart disease (CHD) under artificial circulation (AC). The hemodynamics and parameters of the renin-angiotensin-aldosterone system (RAAS) were examined clinically and biochemically in 100 patients. The findings showed that under hypothermic perfusion with nonpulsing blood flow, plasma renin activator and angiotensin converting enzyme became activated to affect the dynamics of mean arterial blood pressure. A method for RAAS blockage under AC has been developed, which includes administration of sodium thiopental and baralgin during AC. The method provides for reliable prevention of RAAS components activation and guarantees the normalization of the mean arterial pressure in the postperfusion and early postoperative periods.