Effect of a synthetic somatostatin analogue with delayed action (SMS 201-995) on the biliary expenditure in a patient with an external biliary tract fistula
Miranda-Ruiz, R.; Castañón-González, J.; Pérez Aldana, C.; Arias, E.; Díaz de León Ponce, M.; Zárate, A.
Revista de Gastroenterologia de Mexico 55(2): 67-69
1990
ISSN/ISBN: 0375-0906 PMID: 2287871 Document Number: 355507
The effect of treatment with a long acting analogue of somatostatin (SMS 201-995) administered by subcutaneous route 165 micrograms every eight hours in a patient with a external biliary fistula is reported. There was a significant reduction of the daily fistula output during treatment when compared with the basal periods (p = 0.04), with an average decrease of 270 ml/day during the first period of treatment and 357 ml/day when the drug was administered the second time (p = 0.04). There where not changes in the chemical composition of the bile neither adverse side effects were observed during treatment. These results suggest that SMS 201-995 might be useful in the treatment of external biliary fistulas.