Effect of flutoprazepam on skills essential for driving motor vehicles
Moser, L.; Macciocchi, A.; Plum, H.; Bückmann
Arzneimittel-Forschung 40(5): 533-535
1990
ISSN/ISBN: 0004-4172 PMID: 1974429 Document Number: 354917
The effects of the 1,4-benzodiazepine derivative flutoprazepam on the skills essential for driving motor vehicles were tested 2.5 h after intake of 1 .times. 2 mg and 1 .times. 4 mg, comparing with placebo. 18 healthy subjects who had homogeneous results in psychological/physical tests took part in the study. The study had a double-blind, randomized crossover design with 7-day washout periods. 2.5 h after intake of 4 mg flutoprazepam, the ability to drive was impaired. Only a very slight reduction in skill was found at the same time under the influence of 2 mg of the drug.