GABAergic modulation of amnesic trace reproduction by activation of the dopaminergic system
Dubrovina, N.I.; Parkhomenko, R.I.; Il'iuchenok, R.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 110(12): 629-630
1990
ISSN/ISBN: 0365-9615 PMID: 1982083 Document Number: 354180
Features of amnesia trace reactivation by activation of different links of dopaminergic system synaptic apparatus following the change of benzodiazepine, GABAA and GABAB receptors activity are found in experiments in mice. Diazepam pretreatment increases bupropion effectiveness, prolongs duration of enhanced passive avoidance response retrieval during D-1 and D-2 receptors activation by (+)3-PPP and decreases both characteristics under selective D-2 receptor activation by quinpirole. Activation of GABAA and GABAB receptors induces the attenuation of quinpirole effect and the duration of (+)3-PPP action.