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Changes in systemic circulation under induced total spinal block and choice of vasopressors

Kobori, M.; Negishi, H.; Masuda, Y.; Hosoyamada, A.

Masui. Japanese Journal of Anesthesiology 39(12): 1580-1585

1990

ISSN/ISBN: 0021-4892
PMID: 2098585
Document Number: 353945
Total spinal block by using 2% lidocaine 0.5 ml .cntdot. kg-1 (10.0mg .cntdot. kg-1) was carried out in adult mongrel dogs. The effects of atropine 0.02mg .cntdot. kg-1, isoproterenol 0.5 mcg .cntdot. kg-1, methoxamine 0.1 mg .cntdot. kg-1 and ephedrine 0.5mg .cntdot. kg-1 to counteract circulatory changes by total spinal block were studied. Atropine did not exert any marked influence on circulatory system. Isoproterenol elevated HR, LV dp/dt max and CI temporarily, but did not decrease MAP and SVR. Methoxamine elevated MAP and SVR, but decreased CI. Ephedrine is a drug of choice for this situation because it elevated HR, MAP, LV dp/dt max and SVR.

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