Behçet's syndrome. Immunopathologic and histopathologic assessment of pathergy lesions is useful in diagnosis and follow-up
Jorizzo, J.L.; Solomon, A.R.; Cavallo, T.
Archives of Pathology and Laboratory Medicine 109(8): 747-751
1985
ISSN/ISBN: 0003-9985 PMID: 3839376 Document Number: 352
Behcet's syndrome is a complex multisystem disease that, due to the absence of a pathognomonic laboratory test, must be diagnosed using clinical criteria. Clinical pathergy testing, the induction of a sterile pustule 24 h after cutaneous trauma, was proposed as a useful adjunct to diagnosis. This concept was expanded by showing the usefulness of examining pathergy lesions by routine and immunofluorescence microscopy in the diagnosis of 9 patients with Behcet's syndrome. Histopathologic pathergy assessments correlated with clinical disease activity and/or response to experimental oral thalidomide therapy in 5 of 6 patients with Behcet's syndrome who were retested.
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