The development of coronary insufficiency during prolonged treatment of essential hypertension
Kalnins, U.V.; Skarda, I.J.; Liepinja, D.J.; Vitols, A.V.
Cor et Vasa 32(1): 64-71
1990
ISSN/ISBN: 0010-8650 PMID: 2140319 Document Number: 351975
The occurrence of signs of coronary insufficiency during prolonged combined treatment of essential hypertension was analysed in a selected group of 42 patients with left ventricular myocardial hypertrophy. During a four-year antihypertensive therapy 17% of patients developed angina pectoris on effort, myocardial infarction occurred in 7%, and ischaemic ECG changes during bicycle ergometry or transoesophageal atrial pacing were detected in 36%. In the subgroup with an insufficient hypotensive effect and sustained severe myocardial hypertrophy the signs of coronary insufficiency occurred in 53%. Nevertheless, the attainment of a stable pressure normalization and regression of myocardial hypertrophy does not exclude the development of coronary insufficiency, even in patients treated with .beta.-adrenoblocking drugs.