Small intestine transplantation--a causal therapy in short bowel syndrome
Deltz, E.; Schroeder, P.; Schweizer, E.; Gundlach, M.; Gebhardt, H.; Hansmann, M.L.
Schweizerische Rundschau für Medizin Praxis 79(51): 1586-1588
1990
ISSN/ISBN: 1013-2058 PMID: 2270384 Document Number: 351732
The problems of surgical technique, graft physiology and immunological reactions in small-bowel transplantation have been investigated in extended animal experiments. In these experiments, the fundamentals of a successful clinical application of small-bowel transplantation could be laid. A successful human small-bowel transplantation could be carried out by the Kiel Group for the first time in 1988. A graft which had been removed from a related donor showed a complete adaptation after 22 months, so that the patient became completely independent from parenteral nutrition. After that, in several cases small-bowel and combined liver and small-bowel transplantation have been carried out. Thus, the clinical small-bowel transplantation represents the causal therapy of short-bowel syndrome and should be developed in further clinical trials.