Impact of smoking, physical training and weight reduction on FVII, PAI-1 and hemostatic markers in sedentary men
Gris, J.C.; Schved, J.F.; Feugeas, O.; Aguilar-Martinez, P.; Arnaud, A.; Sanchez, N.; Sarlat, C.
Thrombosis and Haemostasis 64(4): 516-520
1990
ISSN/ISBN: 0340-6245 PMID: 2150727 Document Number: 351008
The variations of FVII, PAI-1, TAT complexes, fibrinopeptide A, D-Dimers and beta thromboglobulin plasma levels were studied on 30 sedentary men, smokers and non-smokers, who were admitted to a 6 months' program of physical training and smoking cessation. After 3 months of intervention, sustained physical training was associated with the decrease of FVII and PAI-1 levels. Mild exercise performed during a second 3-month period could maintain normal FVII and PAI-1 activities but participants who stopped the training increased their FVII and PAI-1 plasma levels. FVII was not influenced by smoking habits. Smoking cessation seemed to slightly potentiate the decrease of PAI-1 levels associated with mild exercise. Overweight, FVII and PAI-1 levels were correlated and the weight reduction induced by training was related to the changes in the factors. In smokers, physical exercise was associated with a significant increase of hemostatic markers. This exercise-induced variation disappeared after 3 months of intervention in participants who stopped smoking and reappeared in those who smoked again after 6 months of intervention. This finding was not influenced by the physical training program.