Gastrinoma and carcinoma-carcinoid tumor causing Zollinger-Ellison syndrome
Lászik, Z.; Krenács, T.; Baltás, B.; Karácsonyi, S.; Pap, A.
Morphologiai Es Igazsagugyi Orvosi Szemle 30(2): 106-116
1990
ISSN/ISBN: 0540-889X PMID: 2381429 Document Number: 350468
7 gastrinomes and 1 gastrin-producer complex carcinoma-carcinoid tumor were examined by light and electron microscopical-method and by immunohistochemical method. In six cases, the tumor was in the pancreas or in the wall of duodenum; in two cases its localisation was of extra-gastroenteropancreatic (liver, lymph node). All patients developed Zollinger-Ellison syndrome, three patients bled and one had diarrhea. One patient had other tumors, besides gastrinome, which were characteristic of MEN-I syndrome. By immunohistochemical methods all tumors proved to be gastrin and neuron-specific-enolase positive. In four cases somatostatin positivity, in some cases glucagon, pancreatic polypeptide, S-100 protein, keratin and carcinoembryonal antigen positivity were detected. Relation could not be detected between other polypeptide hormones, produced besides gastrin, and biological behaviour of tumor and clinical symptoms.