Complexes of phorbol tumor promoters with protein kinase C
Kozhemiakina, O.V.; Iaguzhinskiĭ, L.S.
Biokhimiia 55(4): 595-607
1990
ISSN/ISBN: 0320-9725 PMID: 2198948 Document Number: 349964
Based on the literature data, a systematic comparison of relationships between the structures of incomplete and complete phorbol tumor promoters, diacylglycerols and their activities in various biological test-systems was carried out. The specific features of the phorbol esters-protein kinase C complexes responsible for the induction of the first and second stages of the tumor promotion in mouse skin, were established. The type of diacylglycerol binding to protein kinase C which confers to the latter noncarcinogenic properties, was specified.
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