Red blood cell aggregation in diabetes mellitus
Le Devehat, C.; Vimeux, M.; Bondoux, G.; Khodabandehlou, T.
International Angiology a Journal of the International Union of Angiology 9(1): 11-15
1990
ISSN/ISBN: 0392-9590 PMID: 2212794 Document Number: 349950
The aim of this work is to study the red blood cell aggregation in diabetic patients. Investigations have been performed via rheometric technics on four various types of diabetics (diabetics with good metabolic control, diabetics with poor metabolic control, diabetics with a distal angiopathy, without clinical signs, diabetics with a distal angiopathy characterized by cutaneous trophic disorders). Results, compared with those of healthy subjects, show that the reversible phenomenon of erythrocyte aggregation is significantly modified in diabetic. Indeed, the red cell aggregation tendency is found to be increased in diabetics. This hyperaggregation becomes more important when the diabetes is characterized by a poor metabolic control or a distal angiopathy with or without cutaneous trophic disorders. Disturbances of red cell aggregation observed in this report are discussed as a result of plasma protein changes and may confirm the role of hemorheological properties in the pathogenesis of diabetic angiopathy.