Viral etiology of chronic cervicitis and its therapeutic response to a recombinant interferon
Qian, Z.W.; Mao, S.J.; Cai, X.C.; Zhang, X.L.; Gao, F.X.; Lu, M.F.; Shao, X.S.; Li, Y.Y.; Yang, X.K.; Zhuo, Y.A.
Chinese Medical Journal 103(8): 647-651
1990
ISSN/ISBN: 0366-6999 PMID: 2173655 Document Number: 349229
Chronic cervicitis was shown to be related to papillomavirus type 16(HPV-16), herpes simplex virus type 2 and cytomegalovirus (CMV) infections as demonstrated by DNA hybridization technique and virus isolation method from samples taken from erosive and normal cervices. After one course of treatment with recombinant interferon alpha 1 (rIFN-.alpha.1), 93.8% of cases showed clinical improvement and 60% marked improvement. The HPV-16 and HSV detection rates dropped down significantly after rIFN-.alpha.1 treatment as compared with those before treatment. Astragalus membranaceus, a Chinese herbal drug, was shown to be synergic to interferon therapy.