Induction of pituitary tumors in germ-free rats exposed to Aspergillus versicolor
Sumi, Y.; Nagura, H.; Miyakawa, M.
Cancer Research 50(2): 400-402
1990
ISSN/ISBN: 0008-5472 PMID: 2295080 Document Number: 349068
We clarified the role of mold exposure in pituitary tumor induction using 53 germ-free Wistar rats exposed before birth and continually exposed thereafter, to Aspergillus versicolor alone. Rats were autopsied at 540 to 730 days. Untreated germ-free controls were autopsied on day 730. Thirty-three of the 53 monoassociated rats had pituitary tumors (62.3%), while only three of the 41 control germ-free rats had tumors (7.3%). It seems likely that this high incidence of pituitary tumor in the experimental rats is due to metabolites derived from the mold.