Clinical significance of Willebrand's factor in allergic dermatoses in children
Rozhkova, L.E.; Chuprova, A.V.
Pediatriia 12: 34-38
1990
ISSN/ISBN: 0031-403X PMID: 2075061 Document Number: 348755
An original micromethod for assaying Willebrand's factor (WF) was used to measure the content of the protein in 45 children with different allergic dermatoses. WF measurement were at the height of the clinical manifestations and during remissions. It has been established that children with allergic dermatoses manifest a fairly appreciable increase fo WF in the plasma, which is likely to reflect objectively the systematic nature and gravity of vascular endothelium derangement. The increase of WF correlates with the gravity of the clinical manifestations of the disease. As the clinical symptoms were being removed, the level of WF was progressively decreasing. Its normalization attests to a genuine arrest of allergic vasculitis. Platelet activation detected in all the forms of allergic dermatoses in the basis for inclusion of antiaggregation agents into those patients' treatment.