Acute diltiazem poisoning: kinetic and hemodynamics study
Jaeger, A.; Sauder, P.; Bianchetti, G.; Kopferschmitt, J.; Dahlet, M.; Tritsch, L.; Flesch, F.
Journal de Toxicologie Clinique et Experimentale 10(4): 243-248
1990
ISSN/ISBN: 0753-2830 PMID: 2262919 Document Number: 348668
The authors report three cases of diltiazem overdose with hypotension and atrio-ventricular conduction disturbances. Hemodynamic study in 2 cases showed a hyperkinetic state with a decrease of systemic vascular resistances. Diltiazem kinetics studied in 2 cases showed a plasma half life of 5.4 and 8.3 hours, a prolonged absorption until the 28th hours in one case. Treatment included gastric lavage, oral activated charcoal (2 cases), plasma expanders and in 2 cases vasopressors with alpha effects. All three patients recovered.