Correlation of clinical and serological findings in patients with rheumatoid arthritis treated for one year with interferon-gamma
Sprekeler, R.; Lemmel, E.M.; Obert, H.J.
Zeitschrift für Rheumatologie 49(1): 1-7
1990
ISSN/ISBN: 0340-1855 PMID: 2109438 Document Number: 348518
Results of a large therapeutic trial of interferon-gamma in patients with rheumatoid arthritis (RA) are described. Of 110 RA-patients enrolled in this clinical trial, 46 were treated with interferon-gamma for 12 months. During the treatment period, dosage was reduced on an individual basis. There was a correlation between the improvement of clinical parameters, such as pain or morning stiffness, and the improvement of laboratory parameters such as erythrocyte sedimentation rate, anemia, leucocytosis or thrombocytosis. Interferon-gamma was well tolerated, and no organ toxicity was detected.