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Rearrangement of the beta T-cell receptor gene in a monocytoid B-cell lymphoma

Xerri, L.; Horschowski, N.; Lejeune, C.; Carcassonne, Y.; Hassoun, J.

Archives of Pathology and Laboratory Medicine 114(1): 109-111

1990

ISSN/ISBN: 0003-9985
PMID: 2153018
Document Number: 348165
We describe an unusual case of monocytoid lymphoma displaying a rearrangement of the T-cell receptor beta-chain gene associated with a rearrangement of the immunoglobulin heavy-chain gene, and of the lambda light-chain gene. This lymphoma was morphologically similar to previous cases in the literature, and was clinically of low grade. The lymphoma expressed the lambda light chain, HLA-DR, CD21, and CD22. Though the B-cell lineage of this lymphoma seems very likely, the genotypic profile raises a cautionary note regarding the supposed high stage of differentiation of monocytoid lymphomas.

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