Receptor-mediated mechanism of catecholamine damage of the endothelium of major arteries
Kondakov, I.K.; Voĭno-Iasenetskaia, T.A.; Tararak, E.M.
Arkhiv Patologii 51(4): 21-28
1989
ISSN/ISBN: 0004-1955 PMID: 2742526 Document Number: 346273
In 20 rabbits, the mechanism responsible for receptor-mediated lesion and desquamation in the endothelium was studied during isolated aortic perfusion. The screening of catecholamines, artificial adrenoceptor agonists and agents simulating the action of secondary messengers indicated that simultaneous activation of alpha- and beta-adrenoceptors resulted in endotheliocyte death and increased aortic wall permeability. Subsequently, the vasoactive agents entering as a component of transudate the medial aortic tunic caused persistent smooth muscle cell spasm. The resultant compressing tensions of the collagenoelastic carcass of the aorta led to the removal of the transudate from the medial tunic into the subendothelial space through the fenestras of the internal elastic membrane. The removable liquid detached impaired endothelial layers from the membrane surface and lifted it off, forming local distended areas. These areas were torn off by blood flow, uncovering the surface of the internal elastic membrane.