Effect of peptide AS-48 on Enterococcus faecalis subsp. liquefaciens S-47
Galvez, A.; Valdivia, E.; Martinez, M.; Maqueda, M.
Antimicrobial Agents and Chemotherapy 33(5): 641-645
1989
ISSN/ISBN: 0066-4804 PMID: 2473710 Document Number: 345843
The enterococcal peptide As-48 exerts a concentration-dependent bactericidal effect on Enterococcus faecalis subsp. liquefaciens S-47; cell rescue by cardiolipin and trypsin can be effected only in the first few minutes after antibiotic addition. Gramicidin-exposed cells are protected from killing by AS-48. Long-term and pulse incorporation of radiolabeled substrates into trichloroacetic acid-precipitable material, O2 consumption, and the ability to maintain intracellular potassium levels are impaired shortly after addition of AS-48.