Arthropathies following the administration of pefloxacin to an adolescent with mucoviscidosis
Kesseler, A.; Lacassie, A.; Hugot, J.P.; Talon, P.; Thomas, D.; Astier, L.
Annales de Pediatrie 36(4): 275-278
1989
ISSN/ISBN: 0066-2097 PMID: 2742312 Document Number: 345465
We report the occurrence of knee joint effusion with prolonged functional impairment in a 17-year old boy with cystic fibrosis treated with pefloxacin for recurrent lower respiratory tract infections caused by Pseudomonas aeruginosa. Because the quinolone pefloxacin fairly often induces joint disease in pediatric age groups, we advocate restricting its use to those patients whose growth is completed. In growing individuals, it seems reasonable to use second generation quinolones only in infections caused by resistant organisms and to avoid exerting the joints during treatment.