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Hypogammaglobulinemia in infants infected with human immunodeficiency virus

Saulsbury, F.T.

Southern Medical Journal 82(4): 423-425

1989

ISSN/ISBN: 0038-4348
PMID: 2784870
Document Number: 345101
Two premature infants were infected with HIV via blood transfusions during the neonatal period. Although neither patient had serum antibody to HIV owing to severe hypogammaglobulinemia, HIV infection was confirmed by finding HIV antigen in the sera of both patients. These cases show that HIV infection can produce severe hypogammaglobulinemia, and illustrate the value of HIV antigen detection in the diagnosis of HIV infection in seronegative patients.

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