Determination of potential carcinogenicity of nickel-containing dust using a micronuclear test
Kiseleva, A.A.; Lipatov, G.Ia.; Pylev, L.N.; Beresneva, O.Iu.
Gigiena Truda i Professional'nye Zabolevaniya (9): 31-32
1989
ISSN/ISBN: 0016-9919 PMID: 2558977 Document Number: 344867
Mutagenic activity of 3 samples of nickel-containing dusts was experimentally studied in white random-bred rats. Quantity of micronuclei in polychromatophilic erythrocytes of bone marrow smear depended on nickel dust content. Micronuclear test could be used as a rapid method for the determination of potential carcinogenic activity of polymetallic nickel-containing dusts and also as a factor confirming oncologic hazard of chemical substances combined with epidemiologic studies and chronic experiment on animals.