DNA topoisomerases and resistance to anticancer agents
Andoh, T.; Okada, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(3 Part 2): 569-575
1989
ISSN/ISBN: 0385-0684 PMID: 2539786 Document Number: 343772
Since the discovery of several potent anticancer agents which are specific inhibitors of DNA topoisomerases, the key enzymes in the DNA metabolism, efforts to elucidate the mechanism of acquired resistance to these agents and to overcome them have been focused on these enzymes, the cellular targets of the anticancer agents. These trends were briefly reviewed.