Isoniazid-rifampicin-induced submassive hepatic necrosis
Kasantikul, V.
Journal of the Medical Association of Thailand 72(1): 56-58
1989
ISSN/ISBN: 0125-2208 PMID: 2723568 Document Number: 343685
A 58-year-old woman with tuberculosis received antituberculous drugs which included isoniazid, rifampicin, and ethambutol. Nausea and anorexia were initial symptoms while jaundice and abdominal pain were late manifestations. She became comatose and died 7 weeks after therapy. Autopsy revealed submassive necrosis of the liver and active advanced pulmonary tuberculosis. It is, thus, necessary for the physician to be alert for this serious complication in prescribing a combination of these antituberculous drugs.