Factors affecting serum sialic acid levels
Gydow, G.; Sydow, H.; Rücker, K.
Biomedica Biochimica Acta 48(4): 365-369
1989
ISSN/ISBN: 0232-766X PMID: 2751642 Document Number: 343342
Inoculation of certain immunostimulators (BCG, Freund's adjuvant) as well as several antigens or Silasorb resulted in a 2- to 3-fold increase of the serum sialic acid level in mice. In contrast, treatments causing immunosuppression, like .gamma.-radiation and application of cyclophosphamide, did not influence the serum sialic acid level. Furthermore, immunosuppression did not prevent the increase caused by immunostimulators. The results suggest that macrophages may be involved in regulating the serum sialic acid levels after immunostimulation.