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Molecular basis of cisplatin resistance in human carcinomas: model systems and patients

Scanlon, K.J.; Kashani-Sabet, M.; Miyachi, H.; Sowers, L.C.; Rossi, J.

Anticancer Research 9(5): 1301-1312

1989

ISSN/ISBN: 0250-7005
PMID: 2686531
Document Number: 343278
In this review, cisplatin resistance will be summarized. We will discuss characteristics of potential mechanisms of resistance in tissues from patients with ovarian, colon and breast carcinoma. Secondly, a new molecular biology assay will be discussed which detects changes in gene expression in cisplatin-resistant cells. Finally, based on the biochemical and molecular properties of cisplatin-resistant tumors, new strategies to exploit or circumvent cisplatin resistance in human tumors will be entertained.

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